The complete manual fix

  1. Keep an untouched editable source, then export a separate production PDF. Do not optimize the only working copy.
  2. Remove hidden layers, off-canvas objects, unused alternate images, annotations, attachments, crop marks, color bars, and template instructions.
  3. Flatten transparency and artwork for the production file, while keeping title and author type crisp in the source. Embed the fonts used by the export.
  4. Downsample only images that materially exceed the resolution needed at their final placed size. Preserve at least 300 DPI for cover artwork and inspect the effective resolution after scaling.
  5. Use the PDF exporter's optimization setting, then confirm that the result is one unlocked page containing back, spine, and front at the exact full-cover dimensions.
  6. Inspect the optimized PDF at high zoom and compare it with a fresh KDP template before uploading the unchanged file.

Keep the evidence

Save KDP's written notice, the unchanged exported file, the selected print settings, and the template used for comparison. Those records make a support case reproducible, and they are what the technical spec guarantee asks for.